亚硝基谷胱甘肽(57564-91-7)物质数据和安全信息

 一、物质数据

中文名称：S-Nitrosoglutathione

英文名称：亚硝基谷胱甘肽

别名：GSNO

分子式：C10H16N4O7S

分子量：336.32

结构式：

熔点：>170°C (dec.)

外观：粉色固体

保存温度：-20℃

功能作用：在体内的一氧化氮供体，平滑肌松弛，血管舒张，抑制血小板的活化

Cas：57564-91-7

二、安全信息

三、参考文献：

1. The relaxant properties in guinea pig airways of S-nitrosothiols.

A Jansen et. al
Journal of Pharmacology and Experimental Therapeutics, 261(1), 154-160 (1992)

Several cellular constituents of the lung have the capacity to synthesize a factor capable of relaxing smooth muscle which has the physicochemical properties of nitric oxide (NO). In other systems, it has been shown that NO may be stabilized in the ..

2. S-nitroso-glutathione inhibits platelet activation in vitro and in vivo.

M W Radomski et. al
British Journal of Pharmacology, 107(3), 745-749 (1992)

1. The effect of S-nitroso-glutathione (GSNO), a stable nitrosothiol, on platelet activation was examined in vitro and in vivo. 2. The adhesion of human platelets to fibrillar collagen and human endothelial cell monolayers was inhibited by GSNO. 3. ..

3. Activation of GluR6-containing kainate receptors induces ubiquitin-dependent Bcl-2 degradation via denitrosylation in the rat hippocampus after kainate treatment.

Jia Zhang et. al
Journal of Biological Chemistry, 286(9), 7669-7680 (2011)

We previously showed that Bcl-2 (B-cell lymphoma 2) is down-regulated in a kainate (KA)-induced rat epileptic seizure model. The underlying mechanism had remained largely unknown, but we here report for the first time that denitrosylation and ubiqui..

4. S-nitrosation of glutathione transferase p1-1 is controlled by the conformation of a dynamic active site helix.

David Balchin et. al
Journal of Biological Chemistry, 288(21), 14973-14984 (2013)

S-Nitrosation is a post-translational modification of protein cysteine residues, which occurs in response to cellular oxidative stress. Although it is increasingly being linked to physiologically important processes, the molecular basis for protein ..

5. S-nitrosylation of phosphotransfer proteins represses cytokinin signaling.

Jian Feng et. al
Nature Communications, 4, 1529 (2013)

Cytokinin is an essential phytohormone in plant growth and development. In Arabidopsis, cytokinin signalling is mediated by a phosphorelay that sequentially transfers phosphoryl groups from the cytokinin receptors to histidine phosphotransfer protei..

6. S-nitrosoglutathione.

Katarzyna A Broniowska et. al
Biochimica et Biophysica Acta, 1830(5), 3173-3181 (2013)

S-Nitrosoglutathione (GSNO) is the S-nitrosated derivative of glutathione and is thought to be a critical mediator of the down stream signaling effects of nitric oxide (NO). GSNO has also been implicated as a contributor to various disease states. T..

7. Effect of combined oxidative and nitrosative stresses on Staphylococcus aureus transcriptome.

Lígia S Nobre and Lígia M Saraiva
Applied Microbiology and Biotechnology, 97(6), 2563-2573 (2013)

Staphylococcus aureus is a pathogen responsible for severe community- and nosocomially acquired infections. To fight pathogen intrusion, the innate immune system uses a plethora of weapons, with the generation of oxidative and nitrosative stresses a..

8. Nitrosoglutathione generating nitric oxide nanoparticles as an improved strategy for combating Pseudomonas aeruginosa-infected wounds.

Jason Chouake et. al
Journal of drugs in dermatology : JDD, 11(12), 1471-1477 (2012)

Pseudomonas aeruginosa is a community-acquired, nosocomial pathogen that is an important cause of human morbidity and mortality; it is intrinsically resistant to several antibiotics and is capable of developing resistance to newly developed drugs vi..

9. Regulation of guard cell photosynthetic electron transport by nitric oxide.

Attila Ördög et. al
Journal of Experimental Botany, 64(5), 1357-1366 (2013)

Nitric oxide (NO) is one of the key elements in the complex signalling pathway leading to stomatal closure by inducing reversible protein phosphorylation and Ca(2+) release from intracellular stores. As photosynthesis in guard cells also contributes...

10. Nitric oxide activates intradomain disulfide bond formation in the kinase loop of Akt1/PKBα after burn injury.

X-M Lu et. al
International Journal of Molecular Medicine, 31(3), 740-750 (2013)

Severe burn injury is an acute inflammatory state with massive alterations in gene expression and levels of growth factors, cytokines and free radicals. During the catabolic processes, changes in insulin sensitivity and skele..

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