This TMB Is Not Another TMB, What Is The Role of Different TMB?

TMB, an English abbreviation, but represents different substances. In the field of biochemical industry, TMB refers to important diagnostic reagents: 3,3',5,5'-tetramethylbenzidine , in the medical field, TMB refers to the tumor mutational burden. Different TMBs have different functions and applications.

3,3',5,5'-Tetramethylbenzidine（TMB）is a new type of safe chromogen reagent. Compared with traditional chromogen reagents such as benzidine, TMB has higher sensitivity, better stability, safety and other advantages, commonly used biochemical analysis reagents, in vitro diagnostic reagents, used in clinical testing, forensic testing, criminal detection and environment Detection and other fields.

In clinical biochemical testing, TMB is used as a new substrate for peroxidase in enzyme immunoassay (EIA) and enzyme-linked immunosorbent assay (ELISA); in the field of electronic chemistry, TMB can be used as an indicator for highly sensitive and selective colorimetric sensors to detects Ag⁺ and Fe³⁺; in the field of food processing, TMB can be used for the detection of nitrite additives; in the field of criminal investigation, the TMB visualization method is a more commonly used method of occult blood fingerprint development and extraction.

Tumor mutational burden (TMB) is an index reflecting the total gene mutation degree in tumor cells, usually expressed as the total number of tumor somatic mutations contained in the tumor genome region per million bases (Mb). Different types of tumors and the same tumor have different TMB levels in different populations, and in tumors with higher average TMB levels, not all patients have high TMB levels. The proportion of people with high TMB levels in different tumor types different.

Studies have shown that high TMB levels can predict the probability of lung cancer, bladder cancer, melanoma and other tumors responding to immune checkpoint inhibitor drugs. TMB may be an excellent marker for predicting the effect of immunotherapy.

Different TMB have different meanings. This TMB is not another TMB. If you need biochemical reagents, please chose 3,3',5,5'-tetramethylbenzidine (TMB) and its CAS.No.is 54827-17-7 .

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