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New achievements of longevity drugs!
2017-03-30
来源：转载自第三方
30 March 2017
Research on anti-aging and longevity has always attracted widespread attention, and the scientific community has been working hard to achieve the good wishes of people. In addition to the previously known metformin, researchers in various countries have also released a number of related results. This article will summary the new results since 2017 for you.
News of Metformin and resveratrol
An article entitled "Caloric Restriction Mimetics Slow Aging of Neuromuscular Synapses and Muscle Fibers" was published on the journal "The Journals of Gerontology" on March 7, confirming the anti-aging effect of metformin and resveratrol.
Metformin is a therapeutic drug for type 2 diabetes. Earlier this year, the American College of Physicians (ACP) updated the clinical guidelines for the treatment of diabetes and reiterated that metformin remains the first-line drug for patients with type 2 diabetes. In addition, metformin is used in the clinical to treat polycystic ovary syndrome, reduce the risk of cancer in patients with diabetes, and even carry out cancer prevention and treatment in some studies, reduce the prevalence of Parkinson's disease and other potential effect.
Resveratrol is a polyphenolic compound that was first isolated from the roots of a plant veratridine by the Japanese in 1940. Later, people also found its presence in the grapes. And then found that many plants have its presence, such as mulberry, pomegranate, cranberry and blueberries, and even in peanuts. Initially, people regarded it as a plant antitoxin, and later, scientists found that resveratrol has anti-inflammatory, anti-oxidation, and a certain role in protecting the cardiovascular.
Peptide molecules destroy aging cells
On March 23, Cell magazine published an article entitled "Targeted Apoptosis of Senescent Cells Restores Tissue Homeostasis in Response to Chemotoxicity and Aging". A team from the Netherlands found that regular injections of a peptide molecule were able to selectively find and destroy aging cells.
Studies have shown that this anti-aging cell molecules can reverse the aging-related fur loss, impaired renal function and weakness. The mechanism of action of this molecule used in the study is that by interfering with the role of FOXO4-p53, the peptide molecule can induce senescence or suicide of senile cell. It is the first time that people have proven that we can deal with aging cells, and do not bring any obvious side effects, it is a milestone in the field of anti-aging progress. However, such molecules have their limitations, because the digestive system will destroy them, so it can only be administered by inhalation or by injection.
NMN—improves DNA repair
On March 24th, scientists from Harvard Medical School, University of New South Wales published a new article titled "A conserved NAD+ binding pocket that regulates protein-protein interactions during aging" in “Science”. Relevant reports said the discovery is expected to produce revolutionary drugs for reversal of aging and improving DNA repair, and even may help NASA to send astronauts to Mars.
Although our cells have a natural ability to repair DNA damage, this ability will decline as our age grows. Scientists have found that NAD+, a naturally occurring metabolite in every cell of our body, plays a key role in controlling the interaction between proteins that control DNA repair as a regulator. Treatment with NAD+ precursors, known as NMN, they improve the ability of mouse cells to repair DNA damage caused by radiation or senescence. It is reported that human trials on NMN therapy will begin within 6 months.
Astaxanthin compound CDX-085
On March 28, John A. Burns School of Medicine in the University of Hawaii and Cardax recently unveiled the results of an animal study to evaluate the effectiveness of an anti-aging drug astaxanthin compound CDX-085. FOXO3 gene plays a key role in longevity, and in animal experiments, CDX-085 significantly increased the expression of the gene.
Each human body has FOXO3 gene, and one of its variants has been shown to be associated with human longevity and can help humans fight against aging. Professor Wilcox and colleagues from John Burns School of Medicine, University of Hawaii, obtained above results after researching health information of more than 8,000 Japanese Americans for nearly 50 years. By activating the FOXO3 gene in the human body, people can turn it into a "longevity" FOXO3. In this study, the researchers demonstrated that CDX-085 was able to activate the FOXO3 gene. This is the first study to test the potential of astaxanthin to activate FOXO3 gene in mammals. Researchers hope to be able to further confirm the anti-aging effect of astaxanthin in clinical trials to help humans fight against aging.
"Why are we getting old?" This is one of the most fascinating questions, but there is not yet a satisfactory answer. Over the years, scientists have been exploring the truth of aging. We believe that under the continuous efforts of scientists, perhaps one day people can really achieve the wish of anti-aging and longevity, and develop safe and reliable drugs to delay the impact of aging.
Related links: 1,1-Dimethylbiguanide Hydrochloride
Edited by the Editorial Office of Suzhou Yacoo Science Co., Ltd.
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