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The chief culprits of liver injury was first discovered！
2017-06-06
来源：转载自第三方
6 June 2017
Recently, researchers first discovered the main cause of liver fibrosis—interferon λ3 protein, which is the first time that confirmed interferon λ3 (INLF3) protein mutation will lead to liver injury. The study was conducted by researchers at the Westmead Medical Institute in Sydney, Australia, and research has been published in the international journal Nature Genetics.
Liver fibrosis is a pathophysiological process, refers to abnormal connective tissue in the liver caused by a variety of pathogenic factors, is a necessary stage of cirrhosis from the chronic liver disease, such as hepatitis B and hepatitis C. Liver fibrosis happens in the process of liver repair healing process when liver damage, if the injury factors can not be removed for a long time, the process of fibrosis will continue for a long time to develop to cirrhosis. If liver transplantation do not been taken, these patients can only wait for the gradual decline of liver function. Therefore, to find effective drug treatment means to inhibit or reverse liver fibrosis is imminent.
Previously, the international research team led by Dr. Jacob George and Dr. Mohammed Eslam has confirmed that common genetic variants associated with liver fibrosis are located between IFNL3 and IFNL4 on chromosome 9. However, IFNL3, IFNL4 protein, which one can cause liver fibrosis never has the answer. This time, the researchers analyzed liver tissue samples from nearly 2,000 patients with hepatitis C who carried different types of single nucleotide polymorphisms (SNPs) in the IFNL3-IFNL4 region. The results showed that SNPs, which affect the level of interferon λ3, were associated with the process of liver inflammation and hepatic fibrosis, and SNPs that affected the expression level and function of interferon λ4 were not associated with the process of hepatic inflammation and hepatic fibrosis. Researchers have developed a diagnostic tool based on this finding to predict whether a person's risk of fibrosis is high and assess the rate liver disease develops.
At present, we still have no treatment of advanced liver fibrosis, liver transplantation is the only way to treat liver failure. This finding suggests that an increase in the level of interferon λ3 is a major cause of hepatic inflammation and hepatic fibrosis, which reveals an important mechanism of liver tissue injury and provides a new idea for the development of new drugs for the treatment of liver disease.
Related links: How to Choose the Hepatitis B Antiviral Drugs?
Edited by Suzhou Yacoo Science Co., Ltd.
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