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New discovery of Alzheimer's disease in July 2017
2017-07-26
来源：转载自第三方
26 July 2017
Due to the concealment of onset, the burden of personal and social, and no cure, Alzheimer's disease (AD) has attracted more and more attention around the world. Over the years, scientists have been trying to study the factors associated with Alzheimer's disease in order to find a way to treat or prevent it. This article will summarize the new findings of Alzheimer's disease reported in July 2017.
The commonality of Alzheimer's disease and Parkinson
On July 3, a study published in the International Journal of Nature Structural and Molecular Biology, scientists from Emory University studied the commonality of Alzheimer's disease and Parkinson, research may provide hope for the development of new therapies for the treatment of two neurodegenerative diseases.
In Alzheimer's disease (AD) and Parkinson's disease (PD), a viscous protein forms a toxic aggregate in brain cells, which in the AD is a tau protein that is assembled to form a neurofibrillary tangles; While in the case of PD, it is an α-synuclein which forms a Lewy body. Asparagine endopeptidase (AEP) is able to modify the tau protein to make it more viscous and toxic. In this study, the researchers found that AEP also appears to be able to modify the α-synuclein in the same way as tau protein modification. This seems to reveal some commonality between Alzheimer and Parkinson.
Alzheimer's disease may be misdiagnosed
July 19, the US "Washington Post" reported that the interim results of a four-year study show that there is a large number of patients in the treatment may not exist Alzheimer's disease.
Researchers re-positronated 4,000 people by positron emmission tomography who had previously been diagnosed with mild cognitive impairment (MCI) or dementia to verify the existance of amyloid protein, they found that test results of only 53.3% of MCI patients and 70.5% of patients with dementia were positive. This is because in previous judgments, doctors are often based on symptom diagnosis.
Based on this result, the doctor changed the treatment plan for 2/3 patients involved in the study. The researchers also hope that this study will allow medical insurance and Medicaid to include PET scans within Medicare coverage for more accurate diagnosis of Alzheimer's disease.
Snoring may be associated with Alzheimer's disease
On July 21, the Daily Mail reported that a study by Harvard University showed a link between snoring and Alzheimer's disease. In view of the fact that there is no effective treatment for Alzheimer's disease at this stage, the researchers hope that their findings will play a role in the implementation of sleep therapy and prevention of dementia.
Researchers recruited 1752 volunteers, with an average age of 68 years. The researchers asked the volunteers to participate in a sleep experiment, fill out the questionnaire on sleep and accept the psychological function assessment. Previous studies have shown that one in five percent of APOE gene variants are at high risk in dementia. This study of Harvard University shows that people carrying APOE genetic variation, memory loss accelerated in patients with sleep apnea. In addition, there was a correlation between daytime sleepiness and apnea symptoms and impaired attention, memory and slower thinking.
In the treatment of Alzheimer's disease, although there is no cure for drugs, but through the many years of research, scientists developed many drugs, such as cholinesterase inhibitors, anti-amyloid β protein, anti-tau protein phosphorylation, anti-oxidative stress, anti-apoptotic, NMDA receptor antagonists and so on. With the deepening of the study, we believe that mankind will beat Alzheimer's disease one day.
Edited by Suzhou Yacoo Science Co., Ltd.
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