Yacoo provides a variety of raw materials for nucleic acid detection reagents to support win the battle against epidemic prevention and control

Identifing the novel coronavirus(2019-nCoV) quickly and getting an effective isolation treatment on the confirmed cases is the keys to overcome the epidemic during thespecial period of the control and prevention of the novel coronavirus epidemic.

The virus nucleic acid detection by using a PCR-based approach is the most important method for diagnosing the novel coronavirus infection. This method is fast, flexible and universal.

The principle of the nucleic acid detection kit for 2019-nCoV is :RNA was extracted from patient samples, reverse transcription-polymerase chain reaction (RT-PCR) was performed, and the trace amount of virus information in the samples was amplified by the amplification reaction, and finally the signals were read in a fluorescent manner.If the signal is positive after PCR, it can be said that the virus is present (infected) in the sample, otherwise it is not infected.

With the rapid increase in the production capacity of nucleic acid detection kits, the demand for reagent raw materials has also increased dramatically.

According to the public report, the reagents used in the nucleic acid detection kits for 2019-nCoV include Tris, DTT, Guanidine hydrochloride, BSA, etc.Among them, Tris acts as a buffer, and is used to form PCR reaction solution / RT-PCR reaction solution / constant temperature amplification buffer, etc. DTT is often used as a disulfide reducing agent to prevent delayed enzyme inactivation.Guanidine hydrochloride is a strong inhibitor of nucleases, which facilitates the extraction of complete RNA from RNASE-rich tissues.BSA is mostly used as a stabilizer to store and react with restriction enzymes or modified enzymes.

These IVD reagents play an important role in the diagnosis of diseases, especially Covid-19.

       Yacoo Science is a national high-tech enterprise specializing in "IVD Reagents Raw Materials", "New Electronic and Chemical Materials", "Biobuffers" and "Pharmaceutical Intermediates". At present, Yacoo Science can provide nearly 100 kinds of IVD reagent materials, including Tris,DTT,Guanidine hydrochloride, BSA and other reagents.It is worth mentioning that the annual capacity of Tris is 2,000 tons.We hope that we can provide basic raw materials for the development of the vaccine for a novel coronavirus, the development of neutralizing antibodies, and the development of rapid immunodiagnostic reagents.

Related links: Tris, DTT, Guanidine hydrochloride, BSA