A Multifunctional Nano Antibacterial Material with Strong Antibacterial Property

Nano antibacterial materials are a class of materials with antibacterial properties at the nanometer scale. They have outstanding advantages such as large specific surface area and high reactivity. They are widely used in biomedicine, chemical industry, food, environment and other related fields, and play a role in human health.

In recent years, with the enhancement of bacterial resistance and the rapid development of science and technology, research on new nano-antibacterial materials has been increasing. Recently, researchers from Northwest A&F University reported on a new type of nano-antibacterial material, which has constructed a safe and effective antibacterial platform that can completely remove bacteria and is an efficient and stable alternative to "antibiotics".

They infused the NH2-MIL-88B(Fe) peroxidase-like nanomaterial with a small amount of Ag(I) to construct NH2-MIL-88B(Fe)-Ag, a potent and benign “antibiotic” with the ability to eliminate bacteria completely. This versatile system could efficiently convert H₂O₂ into the more toxic ˙OH and release Ag(I) simultaneously, making pathogenic bacteria more vulnerable to be eliminated, which decreased the requirement for the toxic H₂O₂ and high concentration of Ag(I).

More importantly, the in vivo results indicated that the synergistic germicidal system could be used for wound disinfection successfully with excellent antibacterial efficacy and negligible biotoxicity.

This strategy paves the way for the development of integrated antibacterial agents with enhanced antibacterial function and alternative antibiotics.

Reference: Wentao Zhang. et al. Ionic silver-infused peroxidase-like metal–organic frameworks as versatile “antibiotic” for enhanced bacterial elimination. Nanoscale. 2020.DOI: 10.1039/d0nr01471k