Application of BES |CAS：10191-18-1|in medical

Loss of blood volume is also called hypovolemia, which can be caused by physical injury, surgery, internal bleeding and other reasons. The obvious loss of blood volume caused by insufficient blood volume may be fatal if not treated in time. After the occurrence of blood loss, the patient is treated with insufficient blood volume by infusion of crystal liquid or colloidal liquid, which is used as a substitute for lost blood. Examples of known blood substitutes or blood volume enhancers include lactate Ringer solution, Hartmann solution, hydroxyethyl starch and isotonic saline. CN101795558B patent developed a body fluid compatibilizer containing N-substituted sulfamic acid buffer, which specifically includes:
(1) The concentration is 1-12mmol/L N,N-bis (2-hydroxyethyl)- 2-aminoethanesulfonic acid;
(2) Non-inorganic phosphate buffer body fluid compatibilizer solution of calcium ion and magnesium ion with molar concentration ratio of 5:1 to 1:1, in which the concentration of calcium ion is 0.1 to 2.5 mmol/L;
(3) 21-35 mmol/l of bicarbonate ion;
(4) 100~150 mmol/L sodium ion;
(5) 2.5～6.2 mmol/L potassium ion;
(6) 96-126 mmol/l of chloride ion;
The above N, N-bis (2-hydroxyethyl) - 2-aminoethanesulfonic acid is abbreviated as BES , and CAS is 10191-18-1. It is an organic compound with molecular formula of C6H15NO5S and molecular weight of 213.25. BES is a biological buffer, widely used in laboratory research and development and chemical and pharmaceutical synthesis. YACOO can provide customers with high-quality services of BES from gram to ton.

Reference
CN101795558B Body fluid compatibilizer containing N-substituted sulfamic acid buffer.