Application of BES |CAS：10191-18-1|in biological analysis

Urine analysis is a source of information for obtaining anatomical and functional information about the kidneys and urethra. It provides an in-depth understanding of the status of systemic diseases such as diabetes. Currently, most of the real-time detection devices used for urine analysis on the market are semi quantitative, using test strips and test strip readers for urine analysis. Quantitative urine analysis results can be obtained by using automatic urine analyzers in hospitals and clinical laboratories. Due to the large variation in pH of urine samples and the impact of ambient temperature on measurement results, existing quantitative detection methods require diluting the sample to eliminate interference caused by urine. In order to minimize the impact of pH or interference in existing quantitative systems, in addition to strong acids or bases, urine samples are also diluted with a certain volume of buffer solution.
      The buffer solution in CN106255887B patent is selected from one or more of N - (1-acetylamino)-2-aminoethanesulfonic acid, sodium acetate, N-(2-acetylamino) iminodiacetic acid, 2-amino-2-methyl-1-propanol, 2-amino-2-methyl-1,3-propanediol, N - (1,1-dimethyl-2-hydroxyethyl)-3-amino-2-hydroxypropanesulfonic acid, N, N-bis (2-hydroxyethyl) -2-aminoethanesulfonic acid (BES), sodium bicarbonate, N, N-bis (2-hydroxyethyl)-glycine, bis (2-hydroxyethyl) iminotr (hydroxymethyl) methane, 1,3-bis [tri(hydroxymethyl) methylamino] propane 3-(cyclohexylamine)-1-propanesulfonic acid, 3-(cyclohexylamine)- 2-hydroxy-1-propanesulfonic acid, 2 - (N-cyclohexylamine) ethanesulfonic acid, trisodium citrate, N, N-bis (2-hydroxyethyl)-3-amino-2-hydroxypropanesulfonic acid, 4-(2-hydroxyethyl) piperazin-1-ethanesulfonic acid, 4-(2-hydroxyethyl) piperazin-1-propanesulfonic acid, 4-(2-hydroxyethyl) piperazin-1-(2-hydroxy) propanesulfonic acid, 2-morpholineethanesulfonic acid, 3-morpholine-2-hydroxypropanesulfonic acid, piperazin-1,4-bis (2-ethanesulfonic acid) Piperazin-1,4-bis (2-hydroxypropanesulfonic acid), N-[tri (hydroxymethyl) methyl]- 3-aminopropanesulfonic acid, N-[tri (hydroxymethyl) methyl]-3-amino-2-hydroxypropanesulfonic acid, N-[tri (hydroxymethyl) methyl]-2-aminoethanesulfonic acid, N - [tri (hydroxymethyl) methyl] glycine, trihydroxymethylaminomethane, and succinic acid
      The above N, N-bis (2-hydroxyethyl) - 2-aminoethanesulfonic acid is abbreviated as BES , and CAS is 10191-18-1. It is an organic compound with molecular formula of C6H15NO5S and molecular weight of 213.25. BES is a biological buffer, widely used in laboratory research and development and chemical and pharmaceutical synthesis. YACOO can provide customers with high-quality services of BES from gram to ton.

Reference
CN106255887B Urine analysis devices and dry reagents for quantitative urine analysis.