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Scientists can use the new technology to produce self-assembled anti-cancer molecules in minutes
2014-08-05
来源：转载自第三方
Researchers from the University of Warwick, UK, have developed a simple and versatile method that can produce an artificial anti-cancer molecule to simulate the characteristics of the body's natural defense system. This anti-cancer molecule structure is similar to the body's polypeptide structure, can help the body to resist cancer and infection, related research has been published in the international magazine Nature Chemistry.
Researchers said it was being tested in laboratory tests that this artificially resistant anti-cancer molecule can effectively inhibit colon cancer; it is difficult for researchers to produce a large number of peptides, but the new technology developed by researchers in this paper takes only a few minutes to achieve the production of anti-cancer peptide molecules, and the production does not require expensive equipment.
Researchers said that the traditional peptide molecules used as drugs into the body will be neutralized by the body's biochemical defense system, and this new technology can create a complex peptide molecules in chemical self-assembly form, this novel polypeptide structure is called a triple helix structure, which is similar to the form of a 3D helix that forms a native polypeptide molecule.
Researchers Professor Scott said that when the introduction of organic chemistry, amino alcohol derivatives and methyl pyridine can be in the solvent (water or methanol) with ferric chloride mixed to form a stable structure, these structures can form a spiral within a few minutes; once the solvent is removed, the remaining polypeptide mimics will be presented in the form of crystals.
Researchers say new peptide mimetics developed in the laboratory can effectively inhibit the spread of colon cancer cells, and later in their clinical research, they will also confirm its reliability through in-depth study, "Although these polypeptide molecules consist of simple basic elements, and the researchers also found that they had a lower toxicity to bacteria, and their specificity and potential selectivity were worthy of further study." said the investigator Scott.
TAG: Chemical Reagents, Biomedicine
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