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World AIDS Day, efforts made to fight HIV
2017-12-01
来源：亚科官网
1 December 2017
December 1 this year, is the 30th World AIDS Day. AIDS is one of the serious global health threats so far. Although mankind has made significant progress in its global fight against AIDS, including developing key antiretroviral therapy and AIDS prevention tools, there is still no cure for it. So what are some important developments in the treatment of AIDS? This article will summarize for everyone.
Prevent HIV at the initial stage of infection
T-helper cells are an important part of the body's immune system and HIV could integrate into the genome of T cells so that these cells do not effectively resist the invaders and are used by the virus to support its attack until the immune system eventually paralyzed. Doris Wilflingseder, a researcher at Innsbruck Medical University in Austria, conducted a study on the initial stages of HIV infection and found that it is still possible for the human immune system to stop the virus at this stage.
CAR-T cell therapy is expected to fight HIV
Researchers from Perelman College of Medicine, University of Pennsylvania, have improved on a previous attempt to develop a new strategy that could potentially be used to genetically engineer a patient's own immune system cells to fight HIV. Some scientists propose to genetically engineer the patient's own T-cells to fight HIV more effectively.
HIV-infected cells may be cleared
Researchers from Japan's Kumamoto University have developed a novel compound that can effectively destroy HIV. When this compound is introduced into infected cells, the germ of the virus is confined within the host cell, and then these cells will naturally die by the way of apoptosis.
Anti-cancer drug JQ1 reactivates latent HIV
Latent HIV, which can hide in cells for many years, is a key obstacle to cure it. Scientists are exploring two main strategies to solve this problem: reactivating and eradicating this latent HIV or finding a way to permanently silence it. Researchers from the University of California, San Francisco and Icahn County, Mount Sinai, studied drugs that undermine this potential and could eventually be used to treat people with HIV and found that the anti-cancer drug, JQ1, can reactivate latent HIV.
3BNC117 combined with Albuvirtide
In July of this year, Frontier Biotechnologies Inc. in Nanjing signed a cooperation agreement with the U.S. Rockefeller University to obtain a global license to broad-spectrum neutralize the HIV antibody 3BNC117. At present, the company is actively working to fight to begin clinical trials in China and the United States next year at the same time, use this kind of functional antibodies and Albuvirtide to treat AIDS.
Although great progress has been made in the treatment of AIDS in recent years, there is still a long way to go to cure AIDS. We also hope that in the following research, researchers will find more ways to treat and even prevent AIDS, to eliminate this major health threat for mankind.
Edited by Suzhou Yacoo Science Co., Ltd.
