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The new study found: let cancer treatment more efficient

2014-07-29 来源:亚科官网

 Recently, scientists from the British discovery, a presence in the target moleculein the blood vessels can be more effective in treating cancer, today's "natural"(Nature) magazine. The study is completely released. These scientists are from the UK Barts cancer institute.

Focal adhesion kinase (FAK) is a non receptor tyrosine kinase, migration andproliferation activity in cells. Previous studies have confirmed that in a variety oftumor tissues and cell lines have high expression of FAK, suggesting that FAKmay be an effective target for tumor therapy.

Chemotherapy and radiotherapy is destroyed by the DNA to kill cancer cells.Queen Marie University of London, Barts Cancer Institute, the team found that,after chemotherapy or radiotherapy FAK molecules into the body sends signalsto self repair. Found that vascular FAK low levels of tumor, before and after the treatment the more likely achieved complete remission.

This shows that, to develop drugs to remove the cancer blood vessels in FAK may enhance cancer treatment, and to prevent the recurrence of cancer. The main author, the Barts Cancer Institute's Bernardo Tavora said: "this work showed that the sensitivity of cancer treatment, and our body mistakenly try to protect cancer from radiation and chemotherapy induced cell killing effect." The main author, the Barts Cancer Institute's Bernardo Tavora said: "this work showed that the sensitivity of cancer treatment, and our body mistakenly try to protect cancer from radiation and chemotherapy induced cell killing effect."

"Although removed from the vascular FAK can destroy the cancer itself, but it can eliminate cancer using to protect themselves against the treatment barriers."

Cells in the vessel wall to send chemical signals called as tumor cell factor, helpthem against DNA injury repair. Cells in the vessel wall to send chemical signalscalled as tumor cell factor, help them against DNA injury repair. The researchers confirmed that this process needs FAK, not FAK does not transmit these signals,this makes the tumor treatment is more sensitive to DNA damage. Kat Arney,director of Cancer Research UK science media ministry said: "Research on the exciting may clarify the blood vessels in the healthy cells to fight cancer therapy."

He then said: "this study mice completed for scientists brought great hope, can increase the cancer drug treatment effect, the cancer cells are sensitive to drugsused by scientists."



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