Pyrrole ester (99740-00-8) application in the synthesis and production of the note

Pyrrole ester is mainly used for white cell project in the production of urine drychemistry test paper in clinical diagnosis, as a substrate of pyrrole ester lipasepaper blocks is compound 3- (N- tosyl -L- alanyl oxy) -5- phenyl pyrroleabbreviation, English name for the 3- (N-tosyl-L-alaninylazy) -5-phenylpyrrole,molecular formula: C20 H20 N2 O4 S, CAS: [99740-00-8], content: ≥ 99.5%,melting point: 153~155 ℃.

At present, the domestic pyrrole ester synthesis is the main route of synthesis of imitation foreign patent, by cinnamic acid by potassium bisulfate and glycine in alkaline conditions, addition, condensation of 3- hydroxy 5- phenyl pyrrole, thenprotection group protection to get the final product. The harsh conditions, and poor repeatability, product color, easy to get pink products in the lastcrystallization. The use of the note, the note is not stable.