The antibacterial effect of Rifampicin (13292-46-1)

 Rifampin has broad-spectrum antibacterial activity, on tuberculosis, leprosy bacilli and gram positive cocci especially resistant Staphylococcus aureus has a strong antibacterial activity against gram negative bacteria, virus and Chlamydia trachomatis, some also inhibit. The minimum inhibitory concentration ofMycobacterium tuberculosis 0.018mg/l in average, oral therapeutic blood concentrations of 100 times the concentration, it can play a bactericidal action.Anti tuberculosis effect similar with isoniazid, streptomycin and relatively strong.Mycobacterium tuberculosis resistant to rifampicin and plain, it is not alone. With isoniazid, ethambutol combined synergistic effect, and can produce delay resistance. The antibacterial mechanism of rifampicin is specific to inhibition ofDNA dependent RNA polymerase, impedes the synthesis of mRNA in animal cells,RNA polymerase was not affected