CAS：110-26-9|Application of N,N'-Methylenebisacrylamide in Biology

Product Name/English Name：N,N'-Methylenediacrylamide
CAS：110-26-9
Molecular Formula：C7H10N2O2
Article No.：J0008
Structural Formula：

Product Introduction
       N,N'-Methylenediacrylamide is a widely used crosslinking agent with stable quality, high purity, and good performance. It belongs to the thickening agent and adhesive of acrylamide. It is used in Textile manufacturing to produce thickening agent and adhesive, in oil exploitation to produce plugging agent. It is also widely used in various fields such as leather chemicals and printing. In addition, N, N '- methylenebisacrylamide can also be used in biology.

Application of N,N'-Methylenediacrylamide
       Nanocarriers utilize their excellent blood circulation and tumor targeting capabilities to not only deliver therapeutic protein drugs to tumors, reduce toxicity to normal tissues and other parts of the body, but also avoid drug degradation, increase drug half-life, payload, and solubility. However, due to the role of MPS and RES in the blood transport process in the human body, the immune response caused by nano drug carriers greatly limits their application and development in the body, making the carriers quickly cleared and unable to effectively penetrate deep into the tumor, limiting the efficacy of the drug. Therefore, CN112494457A patent has developed a long circulating Zwitterion nano drug carrier in blood and its preparation method. The preparation steps are as follows:
       The protein drug, Zwitterion monomer, carbon-carbon double bond positive monomer, carbon-carbon double bond neutral monomer and cross-linking agent are uniformly dispersed in water under continuous agitation, and the outer layer of the protein drug is coated with Zwitterion monomer, carbon-carbon double bond positive monomer, carbon-carbon double bond neutral monomer and cross-linking agent through electrostatic interaction; The Zwitterion monomer is MPC, the positive monomer containing carbon-carbon double bond is N- (3-aminopropyl) methacrylate, the neutral monomer containing carbon-carbon double bond is acrylamide, and the crosslinking agent is N, N '- methylenebisacrylamide, and matrix metalloproteinase-2;

References
CN112494457A  Long circulating Zwitterion nano drug carrier in blood and preparation method thereof.