The Application of Parylene in medical devices

Parylene is a new type of polymer coating material launched by United Carbon Corporation in the 1960s. It is the common name for paraxylene polymere. At present, according to the different molecular structures, Parylene materials can be divided into various types such as Parylene N, Parylene C, Parylene D, Parylene F, Parylene HT, etc. Parylene C is mainly used as a high-purity passivation layer and dielectric layer in microelectronics and semiconductors. It can also be used as passivation, protection, lubrication and other coatings in microelectronics; In addition, it can also be used as isolation, solidification, and reinforcement materials in biomedical anti-corrosion and cultural relic protection.
Application of Parylene
In the medical field, implantable implants are used to support blood vessels in mammalian bodies, such as the urethra, esophagus, bile duct, intestine, arteries, veins, and peripheral blood vessels. For example, implantable implants can be used to support blood vessels in mammalian bodies that experience abnormal widening or narrowing. In some cases, brackets can be used. These types of prostheses can include frame structures such as stents, stent grafts, and covered stents. However, conventional stents, stent grafts, and covered stents may lack the ability to be clearly seen under fluorescence examination, which may hinder the placement of implantable implants. Therefore, there is a need for non radiative stents, stent grafts, and covered stents, as well as methods for producing non radiative stents, stent grafts, and covered stents.In response to existing issues, the CN115315278B patent provides a stent graft with an opaque marker and its production method. The specific method is as follows:
(1) Process the outer surface of the basic scaffold graft to produce a functionalized surface;
(2) Install a connecting layer on the functionalized outer surface; Install an adhesive layer above the connecting layer; The adhesive layer comprises at least one of Parylene C, ParyleneN, Parylene D, Parylene X, Parylene AF-4, ParyleneSF, Parylene HT, Parylene VT-4 (ParyleneF), ParyleneCF, Parylene A, or Parylene AM.
(3) Etching grooves in the adhesive layer to generate an etching layer; Processing the etching layer; And arrange non radiative markers in the groove to generate a filling groove, thereby generating a non radiative stent graft.

References
CN115315278B Scaffold grafts with opaque biomarkers and their production methods.