Paclitaxel (33069-62-4) nursing and carboplatin chemotherapy in the treatment of ovarian cancer

 Paclitaxel is an effective drug used in the treatment of advanced ovarian cancer,it is a new, unique mechanism of action of anti microtubule drug. And carboplatin for metal complex inorganic platinum, belonging to the non cell cycle specificanticancer drugs, directly on the DNA, and inhibit the growth of tumor. Thesynergistic effect of combination. Therefore, nursing during the treatment is very important. The method of application of paclitaxel taxol: a single dose of 210 ~ 300 mg, intravenous drip adding 5% Glucose Injection or 0.9% Sodium Chloride Injection in 500 ml, 3 h after drops to 400 ~ 600 mg carboplatin added 5%Glucose Injection or 0.9% Sodium Chloride Injection intravenous infusion of 250 ml.

If the weak strong, adverse reactions can be finished after the next day in thepaclitaxel carboplatin. If the weak strong, adverse reactions can be finished afterthe next day in the paclitaxel carboplatin. In the given paclitaxel 30 min before the first infusion of 5% Glucose Injection or 0.9% Sodium Chloride Injection 100 ml, inthe dropping pot with dexamethasone 5 mg, cimetidine 0.4 g, ondansetron 8 mg,20 mg intramuscular injection of diphenhydramine hydrochloride, in order to reduce allergic reactions to drugs. Infusion of paclitaxel must strictly control the number of drops, drop number can not be more than 20 drops of /min just input,there is no reaction after 20 min gradually accelerated, the general infusion of 3h, not too fast after the transfusion used group of liquid drug tube complete inputafter the needle, in order to ensure the accuracy of drug when the needle is pulled out and prevent liquid leakage from the blood vessel, causing tissue necrosis. The paclitaxel plus carboplatin in the treatment of advanced ovarian cancer has 86 cases, have achieved satisfactory results, none of the patients had severe allergic reactions and other complications.